The Bioinformatics Analysis Team, or BAT, was formed in September 2008 and is a small and agile research team combining usefully diverse expertise around horizontal mechanisms of immunity, or disease resistance, or stress response, in humans and plants.
One major branch of our work is the study of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in leukemias and lymphomas, the identification of sequence features and biomedical metadata of clinical significance, a better understanding of the diseases and, eventually, the implementation of risk-adapted, personalized treatment. We have extensively published on subsets of stereotyped B cell receptors, somatic hypermutation patterns, and repertoire biases, mainly in chronic lymphocytic leukemia (CLL). We are currently in the process of making key bioinformatics approaches available through our Antigen Receptors Research Tool / ARResT platform - this has involved work on high-throughput data and their clinical applications within the ESLHO::EuroClonality-NGS Working Group.
Another branch, led by Dr Alexandros Bousios, investigates the impact of the life dynamics of transposable elements (TEs) on host genome evolution and tries to unravel underlying TE-related mechanisms responsible for the plasticity and adaptive capacity of plant genomes, critical knowledge in a changing global environment. Over the last few years, and along with great collaborators, we have delved deep into the lifestyle and history of the ancient Sirevirus genus of the populous Copia LTR retrotransposon superfamily, with a cascade of publications on methods, databases, and insights under the Mapping and Analysis of Sirevirus Elements / MASiVE umbrella.
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